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KMID : 0370220130570060394
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Yakhak Hoeji
2013 Volume.57 No. 6 p.394 ~ p.399
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Immune-stimulating Effects of Polygonum aviculare L. Extract on Macrophages
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Jeoj Chang-Bae
Kim Young-Hoon
Batsur Dulamjav
Tunsag Jigjidsuren
Nho Chu-Won
Pan Cheol-Ho
Lee Jae-Kwon
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Abstract
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In this study we demonstrated whether the extract of Polygonum aviculare L. (PAE) can be applied to the immune- stimulating responses in macrophages (Raw 264.7 cells). Cell viability was determined by WST-8 assay, and all four doses of PAE (5, 10, 20, and 40 μg/ml) had no significant cytotoxicity during the entire experimental period. PAE increased
the production of inducible nitric oxide synthase (iNOS) and nitric oxide (NO), and mRNA expressions and protein levels
of pro-inflammatory cytokines(tumor necrotic factor (TNF)-α, interleukin (IL)-1β and IL-6) in the same cells. These immune-stimulating activities of PAE were found to be caused by the stimulation of NFκB signal and phosphorylation of
MAP kinases (p38, ERK and JNK).
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KEYWORD
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Polygonum aviculare L., macophage, cytokine, inflammation
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